1. トップ
  2. 専門家紹介
  3. 庄野 雄介

庄野 雄介先生 (しょうの ゆうすけ)

庄野 雄介
Doctors Me公認

専門分野

一般内科および血液・腫瘍内科(貧血・白血病・リンパ腫・骨髄腫・その他血液疾患および造血幹細胞移植等)、腫瘍・移植免疫学(癌免疫治療・移植片対宿主病・腸内細菌叢(腸内フローラ)・抗生物質・新規薬剤開発)

プロフィール

北海道大学医学部卒業。日米双方の内科医師免許を所有。医学博士(腫瘍免疫学)。2011年から米国ニューヨークマンハッタンのMemorial Sloan Kettering癌センターに勤務。2017年からブルックリンのSUNY Downstate Medical Center内科勤務併任。日本内科学会認定医、日本血液学会専門医。日米で新規薬剤開発(国際特許取得を含む)・臨床研究の遂行にも携わっている。

所属学会
日本内科学会
日本血液学会
日本造血細胞移植学会
The American Society of Hematology
The European Hematology Association
American Society for Transplantation and Cellular Therapy


論文
※筆頭著者のみ一部抜粋
1. Shono Y, van den Brink MRM. Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer, 2018, 18:283-295.

2. Shono Y, van den Brink MRM. Empiric antibiotic use in allogeneic hematopoietic cell transplantation: should we avoid anaerobe coverage? Blood Adv, 2017, 1:2325-2328.

3. Matsuzawa‑Ishimoto Y*, Shono Y*, Gomez LE, Hubbard‑Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A, Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den Brink MR**, Cadwell K**. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J Exp Med, 2017, 214:3687-3705. *shared first authorship, **shared last authorship.

4. Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Rodriguez KAP, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes CG, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MR*, Jenq RR*. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in mice and human patients. Sci Transl Med, 2016, 8:339ra71. *shared last authorship. (Featured in Science 2016, 352:949-950, Healio, Medical Daily, TheScientist, and EurekAlert).

5. Shono Y, Tuckett AZ, Liou HC, Doubrovina E, Derenzini E, Ouk S, Tsai JJ, Smith OM, Levy ER, Kreines FM, Ziegler CGK, Scallion MI, Doubrovin M, Heller G, Younes A, O’Reilly RJ, van den Brink MR*, Zakrzewski JL*. Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-kB-controlled oxidative stress responses. Cancer Res, 2016, 76:377-389. *shared last authorship.

6. Hubbard-Lucey VM*, Shono Y*, Maurer K, West ML, Singer NV, Ziegler CGK, Lezcano C, Motta ACF, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, Dickinson AM, Holler E, van den Brink MR**, Cadwell K**. Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity 2014, 41:579-591. *shared first authorship, **shared last authorship.

7. Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O’Reilly RJ, van den Brink MR*, Zakrzewski JL*. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Dsicov 2014, 4:578-591. *shared last authorship.

8. Shono Y*, Shiratori S*, Kosugi-Kanaya M, Ueha S, Sugita J, Shigematsu A, Kondo T, Hashimoto D, Fujimoto K, Endo T, Nishio M, Hashino S, Matsuno Y, Matsushima K, Tanaka J, Imamura M, Teshima T. Bone Marrow graft-versus-host disease: evidence of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation Biol Blood Marrow Transplant 2014, 20:495-500. *shared first authorship (Featured in Global Medical Discovery 2014).
等、他共著多数

LinkedIn: https://www.linkedin.com/in/yusukeshono/
Researchgate: https://www.researchgate.net/profile/Yusuke_Shono
MSKCC: https://www.mskcc.org/research/ski/labs/members/yusuke-shono

メッセージ

急性期・慢性期内科一般、また血液内科および癌治療の基礎・臨床の幅広い知識と経験を有します。各種症状やセカンドオピニオンについて、病気の診断・治療・新しいお薬についての情報から医学基礎研究まで幅広いご質問にお答えします。米国における医療システム、渡米臨床研修や基礎研究に関する質問にも幅広くお答えできます。